In our last post, Scents & Sensibilities, we took a deep dive into the world of terpenes, exploring how these aromatic compounds shape the flavours, scents, & subtleties of each cannabis strain. But terpenes don’t work alone—they join forces with cannabinoids like THC & CBD to create what’s known as the entourage effect.

This synergy between terpenes & cannabinoids is key to understanding why some strains make us feel energised, while others help us unwind or ease discomfort. 
Today, we’ll break down how these compounds interact.

Whether you’re seeking relaxation, focus, or therapeutic relief, the interaction between terpenes & cannabinoids offers a more personalised & dynamic cannabis experience.

WHAT ARE CANNABINOIDS?

Like terpenes, cannabinoids are organic compounds found in cannabis that have an impact on the human endocannabinoid system.
While THC & CBD are the main ones that come to mind, there are over 100 other identified cannabinoids, many of which have health benefits.
Unlike terpenes, cannabinoids have mostly neutral flavours & scents.

WHAT ARE TERPENES?

Terpenes are aromatic volatile compounds known as hydrocarbons found in many different plants, not just cannabis. As we explored in our last blog post, terpenes are responsible for the flavour & aroma of certain strains & have a variety of health benefits as well.

WHAT IS THE ENTOURAGE EFFECT?

Terpenes combine forces with cannabinoids like THC & CBD to create what’s known as the entourage effect—a natural synergy that enhances & balances the effects of each compound.

This interaction between cannabinoids & terpenes helps shape the specific effects of different strains. For instance, Myrcene, a terpene with relaxing properties, can boost the soothing effects of an Indica strain, while Limonene’s bright, mood-lifting qualities may amplify the energising effects of a Sativa.

This partnership allows users to experience targeted effects based on the unique terpene & cannabinoid profile of their chosen strain, delivering a more personalised & well-rounded cannabis experience.

TERPENES & CANNABINOIDS: SOME KEY POINTS

• While terpenes are found in a wide variety of plants, cannabinoids are only found within a few numbers of plants.
  
  
• Unlike cannabinoids such as THC, terpenes don’t affect the endocannabinoid system & therefore will not get you high, but they work incredibly well together to elevate the experience.
  
  
• Even if they don’t affect the endocannabinoid system directly, terpenes affect how cannabinoids act in the body (such as changing the amount of THC allowed into the brain) & will have an effect on your overall experience.
  
  
• It’s become clear that terpenes & cannabinoids work best side-by-side to really complement each other’s effects. Without terpenes, cannabinoids often fail to achieve their full potential. And without cannabinoids, terpenes aren’t able to give you the mind & body high you expect from your chosen strain.

Therapeutic Potential of the Terpene-Cannabinoid Synergy

1. Pain Relief

• Caryophyllene + CBD/THC: Caryophyllene, known for its peppery aroma, binds directly to CB2 receptors, which play a role in managing pain & inflammation. When combined with cannabinoids like CBD, which also has anti-inflammatory properties, the combination can enhance pain relief without strong psychoactive effects.
  For more acute pain, adding THC may provide further relief due to its analgesic properties.
  
  
• Pinene + THC: Pinene, with its pine-like scent, has anti-inflammatory effects & can help improve focus.
  When paired with THC, it can offer pain relief while potentially minimising short-term memory effects THC may cause, making it ideal for daytime pain management.

2. Anxiety Reduction

• Linalool + CBD: Linalool, a scented terpene found in lavender, is known for its calming & anti-anxiety properties.
  Combined with CBD, which has anxiety-busting effects, this pairing can create a relaxing experience that soothes anxiety without significant psychoactive effects.
  
  
• Limonene + THC/CBD: Limonene’s bright, citrus aroma can uplift mood & ease stress, making it ideal for addressing anxiety.
  Paired with a balanced THC/CBD ratio, limonene can enhance mood & reduce anxious feelings without overwhelming sedation, making it suitable for social situations or mild anxiety relief.

3. Improved Sleep

• Myrcene + THC: Myrcene, with its musky, herbal aroma, is known for its sedative & muscle-relaxing effects.
  When paired with THC, especially in India-dominant strains, this combination can promote deep relaxation & make it easier to fall & stay asleep.
  
  
• Terpineol + CBD/THC: Terpineol has a subtle floral & fruity aroma & is often used in aromatherapy for its relaxing qualities.
  When combined with either THC or CBD, terpineol can support deeper rest & may enhance the body’s ability to unwind, making it beneficial for those dealing with sleep disorders or insomnia.

4. Increased Bioavailability

• Enhanced Absorption: Certain terpenes, like Caryophyllene, interact with cannabinoid receptors directly, which can potentially enhance the bioavailability of cannabinoids. This interaction may lead to improved absorption & a stronger, longer-lasting effect, especially in therapeutic contexts like chronic pain management.
  
  
• Extended Duration of Effects: The interaction between cannabinoids & terpenes may also increase the duration of effects, allowing for sustained relief. This is particularly beneficial in medical contexts, where patients seek lasting symptom relief without frequent re-dosing.

Our Final Thoughts:

Whether you're seeking relief from pain, a boost in mood, or deeper relaxation, understanding the entourage effect empowers you to make informed choices that best fit your needs.

Next time you’re selecting a strain, keep in mind the unique potential of terpenes & cannabinoids working in harmony—they’re not just enhancing effects, but redefining what cannabis can do for you.

Remember to pop us a message if you need help choosing the right strain for you.

Stay lifted, stay curious, & enjoy the journey.
— The Hey Bud Team 🫶

Sources:

• https://leafwell.com/blog/difference-between-terpenes-and-cannabinoids
• https://www.healthline.com/health/cannabis-terpenes
• https://pmc.ncbi.nlm.nih.gov/articles/PMC9861703/
• https://moderncanna.com/terpene/the-difference-between-terpenes-and-cannabinoids/
• https://www.gvbbiopharma.com/terpenes-vs-cannabinoids-2023-guide/
• https://www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know
• https://pmc.ncbi.nlm.nih.gov/articles/PMC7324885/